Lisa E. Geary, Ph.D.

Patent Agent
Bar/Court Admissions
  • U.S. Patent and Trademark Office
  • Ph.D., Molecular and Structural Biophysics, University of Pittsburgh, 1998
  • B.S., Chemistry, Carnegie Mellon University, 1987

As a Patent Agent in the Firm’s Intellectual Property Group, Lisa assists with the drafting and prosecution of patent applications in a wide range of technology areas.

Lisa holds a B.S. in Chemistry from Carnegie Mellon University and a Ph.D. in Molecular and Structural Biophysics from the University of Pittsburgh. Much of her research has focused on specificity in protein-DNA interactions with emphasis on the links between high-resolution structural information and thermodynamic behavior. Her scientific experience spans a wide range of topics from basic molecular biology and biochemistry to small animal physiology and surgery to biophysics and high resolution protein structure determination.

While Lisa’s training and research focused primarily on biochemistry and biophysics, she has accrued immense experience in a wide range of technology areas through her patent practice. She has:

  • Conducted prior art searches and prepared patentability opinions on over 200 international patent applications in the areas of biochemistry, robotics, organic chemistry, chemistry, pharmaceuticals, biotechnology, materials science, nanotechnology and medical devices
  • Conducted patentability, invalidity, infringement and freedom to operate searches on U.S. and international inventions
  • Drafted patents in the areas of pharmaceuticals, biotechnology, nanotechnology, tissue engineering, chemistry, medical devices, photoconductors, environmental monitoring systems and computer software
  • “Platelet bioenergetic screen in sickle cell patients reveals mitochondrial Complex V inhibition which contributes to platelet activation,” Blood. 2014 Mar 27 [Epub ahead of print]
  • “Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion,” Cardiovasc Research, 101:57-68, 2014
  • “Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase,” Free Radical Biology & Medicine, 53:1440-1450, 2012
  • “Oxygen regulates tissue nitrite metabolism,” Antioxidants & Redox Signaling, 17:951-961, 2012
  • “Human neuroglobin functions as a redox-regulated nitrite reductase,” Journal of Biological Chemistry, 286:18277-18289, 2011
  • “Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner,” Journal of Experimental Medicine, 206:2915-2924, 2009
  • “Mechanisms of coupling between DNA recognition specificity and catalysis in EcoRI endonuclease,” Structure, 12:1775-1788, 2004
  • “The energetics of the interaction of BamHI endonuclease with its recognition site GGATCC,” Journal of Molecular Biology, 307:619-636, 2001
  • “Assay of restriction endonucleases using oligonucleotides,” Methods in Molecular Biology, 148:465-490, 2001
  • “Structural and thermodynamic strategies for site-specific DNA binding proteins,” Structure Folding and Design, 8:1015-1023, 2000
  • “Thermodynamic parameters of specific and nonspecific protein-DNA binding,” Supramolecular Chemistry, 12:143-160, 2000
  • “Energetics of the interaction of BamHI endonuclease with its recognition site,” Invited speaker at New England Biolabs, Beverly, MA, July 1998
  • “Specific binding by EcoRV endonuclease to its DNA recognition site GATATC,” Journal of Molecular Biology, 269:82-101, 1997
  • “Structural adaptations in the interaction of EcoRI endonuclease with methylated GAATTC sites,” EMBO Journal, 15:2870-2882, 1996
    • Member, Pittsburgh Intellectual Property Law Association
    • Member, American Association for the Advancement of Science